Publications Right-click on the title to read the article. 2022 Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis Defective repair of topoisomerase I induced chromosomal damage in Huntington’s disease Towards 3D Bioprinted Spinal Cord Organoids C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons Blood–Brain Barrier Disruption and Its Involvement in Neurodevelopmental and Neurodegenerative Disorders Micro-RNAs Shuttled by Extracellular Vesicles Secreted from Mesenchymal Stem Cells Dampen Astrocyte Pathological Activation and Support Neuroprotection in In-Vitro Models of ALS Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation 2021 Mini-Review: Induced pluripotent stem cells and the search for new cell-specific ALS therapeutic targets Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS Biological and methodological complexities of beta-amyloid peptide: Implications for Alzheimer’s disease research Astrocytic C–X–C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity Emerging Mechanisms Underpinning Neurophysiological Impairments in C9ORF72 Repeat Expansion-Mediated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia 2020 Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease Applications of machine learning to diagnosis and treatment of neurodegenerative diseases Deficits in Mitochondrial Spare Respiratory Capacity Contribute to the Neuropsychological Changes of Alzheimer’s Disease Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson’s disease 2019 A High-throughput and Pathophysiologically Relevant Astrocyte-motor Neuron Co-culture Assay for Amyotrophic Lateral Sclerosis Therapeutic Discovery Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis 2018 Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer’s Disease Lost in translation: microRNAs mediate pathological cross-talk between motor neurons and astrocytes Inosine reverses motor neuron toxicity observed in amyotrophic lateral sclerosis patient astrocytes with an adenosine deaminase deficiency 2017 SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits Can Astrocytes Be a Target for Precision Medicine? High content analysis in amyotrophic lateral sclerosis 2016 New In Vitro Models to Study Amyotrophic Lateral Sclerosis Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis 2015 Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 G93A mouse model of amyotrophic lateral sclerosis Improving Single Injection CSF Delivery of AAV9-mediated Gene Therapy for SMA: A Dose–response Study in Mice and Nonhuman Primates Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS Delayed Disease Onset and Extended Survival in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis after Suppression of Mutant SOD1 in the Motor Cortex 2014 The non-cell-autonomous component of ALS: new in vitro models and future challenges Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS Loss of nuclear TDP‐43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones 2013 Therapeutic AAV9-mediated Suppression of Mutant SOD1 Slows Disease Progression and Extends Survival in Models of Inherited ALS Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis Neural Stem Cells as a Therapeutic Approach for Amyotrophic Lateral Sclerosis 2012 Gene expression profiling in human neurodegenerative disease Gene Delivery Improvement for Treating the Lysosomal Storage Disorder Metachromatic Leukodystrophy 2011 Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis 2010 Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS) 2009 Transcriptional response of the neuromuscular system to exercise training and potential implications for ALS 2007 Microarray Analysis of the Cellular Pathways Involved in the Adaptation to and Progression of Motor Neuron Injury in the SOD1 G93A Mouse Model of Familial ALS Share this:TwitterFacebookLike this:Like Loading...
Ferraiuolo Lab 